Модифицированные гидрогелевые покрытия пролонгированного действия в лечении трофических язв диабетического генеза в эксперименте

Abstract

Цель. Оценить влияние разработанных раневых покрытий на патоморфологические характеристики ран лабораторных животных.

Methods. The study was performed on 240 male laboratory rats after preliminary modeling of alloxan diabetes mellitus, paw ischemia by ligation of the femoral artery, formation of a trophic ulcer by intradermal injection of 0.6 ml of 10% calcium chloride. The developed wound dressings were used in all animals, which were divided into four groups. A clinical assessment of the wound was carried out, the sampling of granulation tissue was performed on the third, seventh and 14th days. Histological material was stained with hematoxylin-eosin and trichrome MSB according to the standard method. A semi-quantitative histological evaluation was used to assess reparative processes.