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  • Публикации учёных ГомГМУ в изданиях РБ и за рубежом
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Biodiversity screening of gut microbiome during the allogeneic hematopoietic stem cell transplantation: data from the real-life clinical practice

Дата публикации
2022
Автор(ы)
Stoma, I.
Uss, M.
Milanovich, N.
Stoma, V.
Gubanova, T.
Moduleva, E.
Iskrov, I.
Uss, A.
Метаданные
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Библиографическое описание
Biodiversity screening of gut microbiome during the allogeneic hematopoietic stem cell transplantation: data from the real-life clinical practice / I. Stoma [et al.] // All Life. – 2022. – Vol. 15, № 1. – P. 547–554.
Аннотация
Biodiversity of a gut microbiome has been shown as an important predictor of transplant-related outcomes and infections in allogeneic hematopoietic stem cell transplantation (HSCT). We conducted a single-center real-life clinical study and implemented a routine gut microbiome diversity monitoring across the course of allogeneic HSCT. Twelve patients (with ALL, AML, CML, biphenotypic leukemia and aplastic anemia) were enrolled in a stool samples collection protocol before the start of HSCT and during a 30-day post-transplant period. We have shown the feasibility of a gut microbiome monitoring in a real-life clinical setting and have proven that the alpha-biodiversity of the microbiome is significantly reduced with HSCT in comparison with the individual patient baseline level (Xdc 72.93; p < 0.001; multivariate Dirichlet analysis), what may be related to the antibiotic use and conditioning regimen. Overall, the gut microbiome biodiversity monitoring may be clinically used in a real-life HSCT setting to identify the high-risk groups for developing bloodstream infections and transplant-related negative outcomes.
Ключевые слова
biodiversity
microbiology
gut microbiome
hematopoietic stem cell transplantation
 
URI
http://elib.gsmu.by/handle/GomSMU/11030
DOI
https://doi.org/10.1080/26895293.2022.2074546
Коллекции
  • 2022 [115]

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